434 research outputs found

    Using web-based language learning activities in the ESL classroom

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    This article looks at ways of using Web-based language learning (WBLL) activities and reports the results of a WBLL project that developed a Web site as a supplementary resource for teaching English as a second language (ESL) and tested the Web site with a group of students in an ESL context. The Web site provides WBLL session plans for ESL teachers, containing three types of WBLL activities: pre-created Web activities for grammar, vocabulary, reading and listening; task-based Web activities that require students to use the Web to produce certain outcomes; and teacher-made Web activities. Participants in WBLL sessions using the Web site showed positive attitudes toward WBLL and expressed the view that they would like to use more Web activities during and outside class time

    Learning about computer-assisted language learning: online tools and professional development

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    The study reported in this chapter investigates computer-assisted language learning (CALL) practitioners' use of online tools and ways of developing their professionalism in the field of CALL. Participants in the study were members of an international association for CALL. They were invited to complete an online questionnaire on a voluntary basis. The questionnaire was employed to collect the participants' demographic information and self-reported data on the use of online tools. It also asked the participants to indicate how they keep up to date with what is happening in CALL. The results of the study indicate that the participants use web search engines, communication tools and social networking sites most frequently among twelve categorised online tools while most participants consider themselves as good or excellent users of the Internet. Many participants often read journal articles or books, read email list messages or connect with others in social networks to learn about new developments in CALL. They also regularly search the web and collect information from blog posts or email list messages. Findings contribute to our understanding of CALL practitioners' experiences with online tools and professional development activities and provide recommendations for teacher training for CALL

    Moving beyond basics: from CALL coursework to classroom practice and professional development

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    This chapter addresses the issue of transfer from computer-assisted language learning (CALL) coursework to language teaching practice and teacher professional development. The study reported in this chapter specifically looks at and examines a formal CALL course offered as an optional course for postgraduate students at an Australian university. It employs surveys and follow-up interviews to investigate how language teachers, who had previously completed the CALL course, use CALL in their teaching situations and how they continue their professional development in CALL. The results of the study indicate that the teachers valued the CALL knowledge and skills they gained in the CALL course as the coursework opened their eyes to the potential of CALL in the classroom and the evaluation of CALL materials. The teachers expressed a desire for more knowledge on how best to integrate CALL as well as for further professional development and training in CALL. Findings enhance our understanding of the impact of CALL coursework on CALL practice in situated contexts and provide practical implications for language teacher education

    Nationalism and reunification: a case study of the inter-Korean border area

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    My research examines the role of nationalism towards Korean reunification and the development projects of Korea's border area. The Korean border is a political boundary fonned by the 1953 Armistice Agreement which ended the Korean War. The boundary and its surrounding areas are restricted due to security reasons and the border area is less developed area compared to other provinces in South Korea. On the other hand, the border area could become an area of economic cooperation between North Korea and South Korea and a milestone of economic integration of the two Koreas. I explore how Korean nationalism would influence concretely on inducing the reunification. And to seek the Korean reunification strategies, I explore nationalism in Korea and relevant case studies such as Cyprus, Germany and Yemen. Specially, I analyze that to ensure environmental sustainability the inter-Korean border area, South Korea's development projects for the reunification needs to be balanced against environmental concerns. In fact, despite the increasing calls for development projects between North Korea and South Korea, the management of the border area's environment is rarely thought of as a common necessity. This research discusses effective development projects concerning part of the South Korean government's reunification strategies and environmental concerns in the border area. This research is based on interviews with key local infonnants conducted in the Korean border area from June 2006 to October 2006. In depth interviews were supplemented with archival and documentary material. And the border people's popular opinion is essential in achieving a community's support for the development projects. Therefore, the border people's attitudes towards the development and the environment have been surveyed in one of the South Korean border cities. The results are discussed in relation to reunification strategies in the Korean border area and the thesis explores South Koreans' aspiration to reunification based on Korean nationalism. In addition, it is argued that there is a linkage between development and environment in the border area. These findings have implications for the effective reunification strategies and management of the border area on the Korean peninsula

    Doing what works: a grounded theory case study of technology use by teachers of English at a Korean university

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    Despite considerable effort and expenditure by the Korean government and universities to promote technology use in tertiary education, few teachers of English in Korea regularly and consistently employ technology in their teaching. Moreover, research into the hindrances and enablers of technology use in English education in Korea has been limited for primary and secondary schools and conspicuously absent on the tertiary level. This case study examines what teachers in a general English department at a private university in Seoul undergo as they consider the use of technology both in and out of classrooms. It attempts to provide a holistic look into teacher decision-making in this context. It employs a grounded theory of investigation underpinned by a close reading of the diffusion of innovations theory by Rogers (2003). Data for the study involves three main techniques: semi-structured interviews, a survey questionnaire, and classroom observations. Analysis follows an iterative, grounded method and includes use of both qualitative and quantitative software programs (Atlas.ti 5.0 and SPSS 16.0 respectively). Results from the study form a substantive theory entitled 'what works' which helps explain the myriad of decisions that teachers make while trying to manage personal (internal) and administrative (external) goals and aims. Further, all decisions within this system are underpinned by 'what works' for teachers in any situation both in terms of reliability and consistency. Implications suggest that the use of technology in the classroom exacerbates preexisting pedagogical and infrastructure issues, leading to inconsistencies in representation and application, as well as an overall limitation of potential use by teachers

    Academic experiences of international PhD students in Australian higher education: from an EAP program to a PhD program

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    For the last few decades, Australia has played a pivotal role in the supply of quality education to international students and other educational industries associated with them. In the higher education sector, in particular, international PhD student numbers continue to increase. However, the limited availability of resources for the students and the lack of investigation concerning the students indicate that there is a need for both higher education providers and other related stakeholders to understand and take into account the difficulties and challenges of international PhD students and their implications in the Australian academic context. While learning a new academic culture in a new country, international PhD students meet situations where they have to deal with a range of language problems, cultural differences and personal matters. The study reported in this article explores international non-English speaking background (NESB) students' experiences with university preparation programs and PhD programs and investigates the issues they face at an Australian university with a focus on factors affecting the NESB students' academic experiences. It provides implications for the teaching of postgraduate preparation programs and the supervision of international NESB PhD students at Australian universities

    Editors' introduction to special theme issue [of International Journal of Pedagogies and Learning]: Meanings emerging in practice (Part 3)

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    This issue publishes the third and final set of refereed papers from the first wave proceedings of the 3rd International Conference on Pedagogies and Learning, held at the Springfield Campus of the University of Southern Queensland in Australia on 27 and 28 September 2007. This third conference in the series focused on “Meanings Emerging in Practice” as a lens for examining and evaluating multiple enactments of pedagogies and learning

    UVB Induces HIF-1α-Dependent TSLP Expression via the JNK and ERK Pathways

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    Thymic stromal lymphopoietin (TSLP) may have a key role in the initiation and maintenance of allergic inflammatory diseases, including atopic dermatitis. The present study revealed that UVB radiation exposure could induce TSLP expression in human keratinocytes and a human skin equivalent model. In addition, we investigated the regulatory mechanism of UVB-induced TSLP expression in keratinocytes. TSLP expression was upregulated by transfection with pcDNA3–hypoxia-inducible factor (HIF)-1α (P402A and P564A), which stably expresses HIF-1α protein. UVB-induced TSLP induction in keratinocytes was suppressed in the treatment of mitogen-activated protein kinase inhibitors or small interfering RNAs against HIF-1α. The results of chromatin immunoprecipitation assays indicate the direct involvement of HIF-1α in UVB-mediated TSLP induction. Taken together, these findings indicate that UVB exposure may increase TSLP expression through a HIF-1α-dependent mechanism via the c-JUN N-terminal kinase and extracellular signal-regulated kinase pathways in human keratinocytes. Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2–attracting chemokine (c–c motif) ligand 17 by human dendritic cells. The present study suggests an important role of HIF-1α in UVB-mediated immune response in keratinocytes

    JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin

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    <p>Abstract</p> <p>Background</p> <p>Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee venom) have anti-inflammatory effect by reacting with the sulfhydryl group of p50 of nuclear factor-kappa B (NF-κB) and IκB kinases (IKKs). Since mitogen activated protein (MAP) kinase family is implicated in the NF-κB activation and inflammatory reaction, we further investigated whether activation of MAP kinase may be also involved in the anti-inflammatory effect of melittin and bee venom.</p> <p>Methods</p> <p>The anti-inflammatory effects of melittin and bee venom were investigated in cultured Raw 264.7 cells, THP-1 human monocytic cells and Synoviocytes. The activation of NF-κB was investigated by electrophoretic mobility shift assay. Nitric oxide (NO) and prostaglandin E<sub>2 </sub>(PGE<sub>2</sub>) were determined either by Enzyme Linked Immuno Sorbent Assay or by biochemical assay. Expression of IκB, p50, p65, inducible nitric oxide synthetase (iNOS), cyclooxygenase-2 (COX-2) as well as phosphorylation of MAP kinase family was determined by Western blot.</p> <p>Results</p> <p>Melittin (0.5–5 μg/ml) and bee venom (5 and 10 μg/ml) inhibited lipopolysaccharide (LPS, 1 μg/ml) and sodium nitroprusside (SNP, 200 μM)-induced activation of c-Jun NH2-terminal kinase (JNK) in RAW 264.7 cells in a dose dependent manner. However, JNK inhibitor, anthra [1,9-cd]pyrazole-6 (2H)-one (SP600215, 10–50 μM) dose dependently suppressed the inhibitory effects of melittin and bee venom on NF-κB dependent luciferase and DNA binding activity via suppression of the inhibitory effect of melittin and bee venom on the LPS and SNP-induced translocation of p65 and p50 into nucleus as well as cytosolic release of IκB. Moreover, JNK inhibitor suppressed the inhibitory effects of melittin and bee venom on iNOS and COX-2 expression, and on NO and PGE<sub>2 </sub>generation.</p> <p>Conclusion</p> <p>These data show that melittin and bee venom prevent LPS and SNP-induced NO and PGE<sub>2 </sub>production via JNK pathway dependent inactivation of NF-κB, and suggest that inactivation of JNK pathways may also contribute to the anti-inflammatory and anti-arthritis effects of melittin and bee venom.</p

    Production of transgenic first filial puppies expressing mutated human amyloid precursor protein gene

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    Propagation of transgenic animals by germline transmission using assisted reproductive technologies such as in vitro fertilization (IVF) is the most efficient way to produce transgenic colonies for biomedical research. The objective of this study was to generate transgenic puppies from a founder dog expressing the mutated human amyloid precursor protein (mhAPP) gene. Experiment I assessed the characteristics of the semen prepared by freshly diluted, swim-up, and Percoll gradient methods using a computer-assisted semen analyzer (CASA). Motile and progressively motile sperm counts were higher in the Percoll gradient samples (p &lt; 0.05) than in the swim-up and freshly diluted samples. In Experiment II, a total of 59, 70, and 65 presumptive zygotes produced by fresh, Percoll gradient, and swim-up methods, respectively, were transferred to surrogates (5 for each group); the Percoll gradient (27.27%) and swim-up samples (14.29%) showed the highest blastocyst formation rates, while fresh diluted semen did not produce any blastocyst. Experiment III examined the full-term developmental ability of embryos. Among the 5 surrogates in the Percoll gradient group, one (20.0%) became pregnant; it had 4 (6.15%) sacs and delivered 4 (6.15%; 2 males and 2 females) live puppies. Among the 4 puppies, 2 (50.0%) were found to transmit the transgene on their nail and toe under GFP fluorescence. Furthermore, the integration and expression of the mhAPP transgene were examined in the umbilical cords of all the IVF-derived puppies, and the presence of the transgene was only observed in the GFP-positive puppies. Thus, semen prepared by the Percoll method could generate transgenic puppies by male germline transmission using the IVF technique. Our result will help propagate transgenic dogs efficiently, which will foster human biomedical research
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